Age,blood eosinophils,FeNO and serum IgE as biomarkers for the prediction of eosinophilic phenotype among asthmatic patients
10.12092/j.issn.1009-2501.2025.05.006
- VernacularTitle:年龄、血液嗜酸性粒细胞、FeNO和血清IgE作为预测哮喘患者嗜酸性表型的生物标志物
- Author:
Jiameng GAO
1
;
Yuan MA
;
Yao SHEN
;
Fang WANG
;
Yuhao QIAN
;
Zhihong CHEN
Author Information
1. 复旦大学附属中山医院呼吸科,上海 200000;上海市浦东医院复旦大学附属浦东医院呼吸科,上海 200100
- Publication Type:Journal Article
- Keywords:
eosinophils asthma;
noneosinophilic asthma;
induced sputum;
nomogram;
pridiction
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(5):631-639
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To identify surrogate clinical bio-markers for profiling the eosinophilic status of an individual patient over induced sputum analysis.METHODS:We conducted a cross-sectional study on 100 asthmatic patients whose induced sputum was successfully collected.Subjects were further classified into either EA or NEA based on whether the percentage of sputum eosinophil count(SEC％)was≥3％.Demographic and clinical data were col-lected,including basic information,routine blood tests,lung function tests,bronchodilator reversibili-ty tests,fractional exhaled nitric oxide(FeNO),the Asthma Control Test(ACT)and the Asthma Control Questionnaire(ACQ).All variables significantly asso-ciated with EA were candidates for multivariate lo-gistic regression analysis.A scoring system present-ed as a nomogram for the prediction of EA was de-veloped.RESULTS:In the univariate analysis,com-pared with NEA subjects,those with EA were of older age and had worse asthma control and lung function in addition to higher values of blood eosin-ophils,serum IgE and FeNO.Multivariable logistic regression analysis revealed that age,FeNOx serum IgE and blood eosinophil count(BEC)were identi-fied as independent risk factors for eosinophilic asthma,which were all included in the nomogram.CONCLUSION:A combination assessment including age,FeNOx serum IgE and BEC could be applicable to clinicians in identifying eosinophilic asthma and is easier,faster,more inexpensive and more readily available than the induced sputum test.
