Targeting ferroptosis offers a novel therapeutic approaches in epilepsy
10.12092/j.issn.1009-2501.2025.06.013
- VernacularTitle:靶向铁死亡与癫痫治疗研究进展
- Author:
Yahong ZHAO
1
;
Qiang LI
1
Author Information
1. 赤峰学院附属医院神经内科,赤峰 024005,内蒙古
- Publication Type:Journal Article
- Keywords:
epilepsy;
ferroptosis;
ferroptosis in-hibitors;
neuroprotection
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(6):828-834
- CountryChina
- Language:Chinese
-
Abstract:
Epilepsy is sudden,recurrent,and transient central nervous system dysfunction caused by abnormal discharge of neurons in the brain.Recurrent or prolonged seizures can result in neuronal damage and cell death;however,the mo-lecular mechanisms underlying the epilepsy-in-duced damage to neurons remain unclear.Ferrop-tosis,a novel type of regulated cell death(RCD)characterized by iron-dependent lipid peroxidation,is involved in the pathophysiological progression of epilepsy.Emerging studies have demonstrated pharmacologically inhibiting ferroptosis can miti-gate neuronal damage in epilepsy.In this review,we briefly describe the core molecular mechanisms of ferroptosis and the roles they play in contribut-ing to epilepsy,highlight emerging compounds that can inhibit ferroptosis to treat epilepsy and associ-ated neurobehavioral comorbidities,and outline their pharmacological beneficial effects.The cur-rent review suggests inhibiting ferroptosis as a ther-apeutic target for epilepsy and associated neurobe-havioral comorbidities.
