Correlation Analysis of Serum TNFSF15,GDF11 Expression Levels and In-stent Restenosis after PCI in Patients with Unstable Angina Pectoris
10.3969/j.issn.1671-7414.2025.02.015
- VernacularTitle:不稳定型心绞痛患者血清TNFSF15,GDF11表达水平与PCI术后支架内再狭窄的相关性分析
- Author:
Tianyu LI
1
;
Lingxiu MENG
1
;
Shengnan FAN
1
;
Wenyang SUN
1
Author Information
1. 秦皇岛市第二医院心血管内一科,河北 秦皇岛 066600
- Publication Type:Journal Article
- Keywords:
unstable angina pectoris;
percutaneous coronary intervention therapy;
in-stent restenosis;
TNF superfamily 15;
growth differentiation factor 11
- From:
Journal of Modern Laboratory Medicine
2025;40(2):83-86
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum TNF super family 15(TNFSF15),growth differentiation factor 11(GDF11)and in-stent restenosis(ISR)in patients with unstable angina pectoris(UAP)undergoing percutaneous coronary intervention(PCI).Methods A total of 350 UAP patients who underwent PCI treatment in the Second Hospital of Qinhuangdao from January 1,2020 to January 1,2021 were collected as observation subjects,and they were separated into non-ISR group(n=246)and ISR group(n=104)based on whether they had experienced ISR.ELISA was applied to determine the levels of serum TNFSF15 and GDF11,ROC curve was applied to analyze the predictive value of serum TNFSF15 and GDF11 levels for postoperative ISR in UAP patients after PCI,and multivariate Logistic regression was used to analyze the factors affecting the occurrence of ISR in UAP patients after PCI.Results Compared with the non-ISR group,the ISR group showed an increase in blood glucose,smoking history and LDL-C levels(t/χ2=22.908,18.869,47.337),as well as elevated serum TNFSF15 levels(16.97±1.51 pg/ml vs 18.35±1.62pg/ml)and GDF11 levels(157.72±16.13pg/ml vs 174.11±18.65 pg/ml)decreased(t=7.429,7.811),and the differences were statistically significant(all P<0.001).The AUC(95%CI)of serum TNFSF15 and GDF11 in dependently and jointly predicting ISR after PCI in UAP patients were 0.764(0.716～0.808),0.781(0.734～0.823)and 0.849(0.807～0.885),respectively,and the joint prediction of the two was higher than the individual prediction(Z=4.365,3.257,all P<0.001).Multivariate Logistic regression analysis of serum TNFSF15,the level of GDF11 was a protective factor for ISR in UAP patients after PCI(Wald χ2=11.000,36.321,all P<0.05).Conclusion The serum levels of TNFSF15 and GDF11 decreased in UAP patients with postoperative ISR after PCI,which have good predictive value for the occurrence of ISR in UAP patients after PCI.
