Clinical features of ulcerative colitis complicated with hyperuricemia and the role of hyperuricemia in ulcerative colitis
10.12092/j.issn.1009-2501.2025.06.007
- VernacularTitle:溃疡性结肠炎合并高尿酸血症患者的临床特征及高尿酸在溃疡性结肠炎中的作用
- Author:
Hongxin CHEN
1
;
Lei ZHU
1
;
Jingyi HU
1
;
Hong SHEN
1
Author Information
1. 南京中医药大学附属医院消化内科,南京 210004,江苏
- Publication Type:Journal Article
- Keywords:
ulcerative colitis;
hyperuricemia;
uric acid;
clinical characteristics
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(6):781-788
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To study the clinical characteris-tics of hyperuricemia(HUA)in ulcerative colitis(UC)patients and the role of uric acid in UC through clinical and animal experiments.METH-ODS:The clinical research included UC patients hospitalized for the first time in the Department of Gastroenterology,Affiliated Hospital of Nanjing Uni-versity of Chinese Medicine from April 2019 to April 2023.The patients were divided into two groups based on the presence of HUA,and the clin-ical data and laboratory indicators were collected.In the animal experiment,24 SPF male C57BL/6J mice were randomly divided into ctrl group(Ctrl),model group(DSS),potassium oxonate group(PO),and uric acid group(UA).The body mass index,dis-ease activity index(DAI)score,pathology,inflam-mation,and intestinal barrier function indexes were compared among groups.RESULTS:The clini-cal research showed that the prevalence of HUA in UC patients was 9％(41/455).Patients with HUA had a significantly higher proportion of male and BMI levels,and more extensive colonic types(P＜0.05)than those without.In laboratory indicators,patients with HUA had significantly higher levels of C-reactive protein and triglyceride,and a substan-tially lower level of high-density lipoprotein choles-terol(P＜0.05)than those without.The animal ex-periment found that compared with the Ctrl group,the DSS group significantly decreased body weight,shortened colon length,and increased DAI score.Pathological results showed a large number of in-flammatory infiltrations and significant damage to the crypt structure.Moreover,the expression level of IL-6 in colon tissue was significantly increased,and the expression levels of MUC-2 and ZO-1 were significantly decreased(P＜0.05).Compared with the DSS group,both the PO group and UA group could aggravate the above symptoms,indicating that uric acid has a significant pro-inflammatory ef-fect on DSS-induced UC model mice.CONCLUSION:HUA is not uncommon in UC patients and such pa-tients have a wider range of lesions and more se-vere inflammation.The mechanism may be that high uric acid aggravates inflammation.
