Application of Nomogram model based on two-dimensional shear wave elastography combined with biochemical indicators in the diagnosis of moderate and severe metabolic-associated fatty liver disease
10.16753/j.cnki.1008-2344.2025.01.009
- VernacularTitle:基于二维剪切波弹性成像联合生化指标的列线图模型在中重度代谢相关脂肪性肝病诊断中的应用价值
- Author:
Kun WANG
1
;
Junli WANG
1
;
Yimin WU
1
;
Yu ZHANG
1
;
DaoJing XU
1
Author Information
1. 华东师范大学附属芜湖医院(芜湖市第二人民医院)超声医学科,安徽 芜湖 241000
- Publication Type:Journal Article
- Keywords:
metabolic-associated fatty liver disease;
two-dimensional shear wave elastography;
biochemical indicators;
Nomogram
- From:
Journal of Shenyang Medical College
2025;27(1):48-54
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical value of the Nomogram model based on two-dimensional shear wave elastography(2D-SWE)combined with biochemical indicators in the diagnosis of moderate and severe metabolic-associated fatty liver disease(MAFLD).Methods:A total of 170 patients with MAFLD diagnosed by ultrosound image in the health management center of the Second People's Hospital of Wuhu from Jan 2023 to Dec 2023 were divided into mild,moderate and severe groups according to two-dimensional ultrasound images,and 111 healthy volunteers were recruited as control group in the same period.Multivariate logistic regression analysis was used to screen independent risk factors for moderate and severe MAFLD and construct a predictive model.The diagnostic efficacy of the ROC model was plotted,and the Nomogram model was used to conduct internal verification.Results:Multivariate logistic regression analysis showed that liver stiffness measurement(LSM),platelet count(PLT)and hepatic steatosis index(HSI)were the independent risk factors for the diagnosis of moderate and severe MAFLD.The area under the curve(AUC)of LSM,PLT and HSI was 0.940(95%CI:0.911-0.969),with a sensitivity was 87.5%and a specificity was 88.1%.The internal validation showed that the model had high accuracy and stability.Conclusion:The Nomogram model based on LSM combined with PLT and HSI can effectively diagnose moderate and severe MAFLD,providing a reliable evidence for early clinical intervention and adjustment of therapeutic measures.
