Role and mechanism of dexmedetomidine alleviating sepsis-induced lung injury
10.12092/j.issn.1009-2501.2025.05.014
- VernacularTitle:右美托咪啶减轻脓毒症肺损伤的作用与机制
- Author:
Hong CHANG
1
;
Junchao LIU
;
Sijie CHEN
;
Jianqing ZHAO
;
Zigang ZHAO
Author Information
1. 河北北方学院基础医学院/微循环研究所,张家口 075000,河北;河北省急危重症发病机制及干预重点实验室,张家口 075000,河北
- Publication Type:Journal Article
- Keywords:
dexmedetomidine;
sepsis;
acute lung injury
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(5):695-701
- CountryChina
- Language:Chinese
-
Abstract:
The sepsis and sepsis-induce lung inju-ry threats seriously human health.Dexmedetomi-dine(DEX),a sedative drug,plays an active role in preventing sepsis-induced lung injury during the ba-sic and clinical practice.The current article reviews the role and mechanism of DEX dexmedetomidine alleviating sepsis-induced lung injury from the as-pects of inflammation,oxidative stress,apoptosis,mitochondrial dynamics,autophagy,vascular per-meability,neuro-regulation,targeting miR-128-3p/MAPK14 and DNA methylation,etc.This review looks forward to deepen the understanding the ap-plication of DEX in the field of critical care medi-cine,expand the pharmacological effect of DEX and provide a new idea for the prevention and treat-ment of sepsis from the sedation approach.
