Advances in the anti-fibrosis effect of oxidative stress-related regula-tory protein Cygb
10.12092/j.issn.1009-2501.2025.05.012
- VernacularTitle:氧化应激相关调控蛋白Cygb抗纤维化作用的研究进展
- Author:
Dongli YANG
1
;
Jing LI
1
;
Lifang DUAN
1
;
Wenjiang ZHANG
1
;
Na LI
1
;
Hong ZHANG
1
Author Information
1. 陕西中医药大学,咸阳 712046,陕西
- Publication Type:Journal Article
- Keywords:
cytoglobin;
oxidative stress;
fibrosis
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(5):683-689
- CountryChina
- Language:Chinese
-
Abstract:
Cytoglobin(Cygb)is a recently discov-ered astrocyte specific globin that is widely distrib-uted in mammalian visceral organs such as the lung,heart,spleen,liver,pancreas,stomach,small intestine,kidney,neuron,and bone tissue.It plays an important role in clearing reactive oxygen spe-cies,nitric oxide and nitrite signal transduction,al-leviating oxidative stress,anti-fibrosis,regulation of cell apoptosis and treatment of cancer,etc.It is worth noting that the anti-fibrosis role of Cygb has attracted increasing attention in recent years.The existing research has involved various fibrotic dis-eases such as the liver,pancreas,kidney,spleen,etc.,especially in the study of liver fibrosis,which has made great progress.This article system re-views the role of Cygb in various fibrotic diseases,with a focus on its mechanism of alleviating oxida-tive stress.Although the application of Cygb in fi-brotic diseases is still in its infancy and the underly-ing mechanisms still require extensive research and exploration,there is no doubt that Cygb can serve as a promising therapeutic target,with the poten-tial to be widely used in the prevention and treat-ment of fibrotic diseases.
