Analysis of Related Factors Affecting Prognosis after Initial Treatment of Pri-mary Vulvar Malignant Tumor
- VernacularTitle:原发性外阴恶性肿瘤初始治疗后影响预后的相关因素分析
- Author:
Le ZHENG
1
;
Haiqing JIA
1
Author Information
1. 大连理工大学附属肿瘤医院辽宁省肿瘤医院妇科,辽宁沈阳 110042
- Publication Type:Journal Article
- Keywords:
Primary malignant tumor of the vulvar;
Initial Treatment;
Risk factors;
Survival prognosis
- From:
Journal of Practical Obstetrics and Gynecology
2025;41(2):158-163
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the related factors affecting the prognosis of primary vulvar malignant tumors after initial treatment.Methods:The clinical and follow-up data of 228 patients with primary malignant tumor of the vulvar who received initial treatment at Liaoning Cancer Hospital from January 1,2005 to September 30,2018 were collected.Univariate and multivariate Cox regression analysis were used to identify factors affecting the overall survival rate(OS)of primary vulvar malignancies.Results:The median age of 228 patients of primary vulvar ma-lignant tumors was 55(15-80),with a median follow-up time of 78 months.The 3-year progression free survival(PFS)rate was 72.8％,the 3-year OS rate was 76.4％,the 5-year OS was 70.7％.The results of univariate anal-ysis showed that age,tumor diameter,lymph node metastasis,clinical stage and treatment method were all related to 5-year OS(P＜0.05),Multivariate COX regression analysis showed that age＞60 years(OR 3.96,95％CI 1.90-6.01),tumor diameter＞4 cm(OR3.58,95％CI 2.02-6.37),and lymph node metastasis(OR 1.85,95％CI 1.28-3.00)were independent risk factors affecting 5-year OS after initial treatment(P＜0.05).Conclusions:Age,tumor diameter and inguinal lymph node status are related factors that affect the prognosis of primary vulvar malignant tumors after initial treatment.If high-risk factors exist,such as lymph node metastasis after operation or large tumor lesions,it is recommended to supplement radiotherapy and chemotherapy to improve survival progno-sis.
