Effects of Menopausal Hormone Therapy on Bone Turnover Markers in Meno-pausal Women
- VernacularTitle:绝经激素治疗对绝经期女性骨转换标志物的影响
- Author:
Wei WANG
1
;
Hongxia HU
1
;
Xiaole SUN
1
Author Information
1. 北京大学第三医院妇产科,北京 100191
- Publication Type:Journal Article
- Keywords:
Menopausal hormone therapy;
Postmenopausal women;
Bone turnover markers;
Bone mineral density
- From:
Journal of Practical Obstetrics and Gynecology
2025;41(2):125-129
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To understand the impact of menopausal hormone therapy(MHT)on bone turnover markers(BTMs)in menopausal women and explore the feasibility of BTMs as efficacy monitoring indicators for MHT.Methods:Menopausal women who visited the Menopause Clinic and Gynecological Endocrine Clinic of our hospital from January 2018 to August 2022,received MHT and had regular reexaminations of BTMs were selected.According to the treatment plan at the initiation of MHT,they were divided into the estrogen group(continuous or cyclic sequential therapy or continuous combined therapy)and the tibolone group.All patients had reexaminations of BTMs,including osteocalcin(OC),beta C-terminal telopeptide of type Ⅰ collagen(β-CTX),and procollagen type Ⅰ N-terminal propeptide(P1NP),before treatment and at 6 months,12 months and 24 months after treatment.Meanwhile,their bone mineral density examination results in our hospital were collected.The BTMs before and af-ter treatment in each group were compared,as well as the changes in BTMs after treatment compared with those before treatment between the two groups.Meanwhile,the changes in bone mineral density were analyzed.Results:The levels and abnormal rates of BTMs(β-CTX,P1NP,OC)in both the estrogen group and the tibolone group were significantly decreased at 6,12,and 24 months after treatment compared with those before treatment,and the differences were statistically significant(P＜0.05).When comparing the changes in BTMs after treatment compared with those before treatment between the two groups,there was no statistically significant difference(P＞0.05).The incidences of osteopenia and osteoporosis in patients at 12 months and 24 months after treat-ment had no significant changes compared with those before treatment,and the differences were not statistically significant(P＞0.05).The lumbar spine bone mineral density was significantly improved at 12 months and 24 months after MHT treatment compared with that before treatment,and the differences were statistically significant(P＜0.05).The bone mineral densities of the femoral neck and hip were not significantly improved at 12 months and 24 months after MHT treatment compared with those before treatment,and the differences were not statisti-cally significant(P＞0.05).Conclusion:The anti-bone resorption effects of the two MHT regimens are similar.The BTMs(OC,β-CTX,PINP)are significantly decreased after 6 months of treatment and can maintain their ef-fectiveness.BTMs can be used as one of the important monitoring methods for the efficacy of menopausal hor-mone therapy.
