Study on the Correlation between Serum NSE Levels and Recurrence after Percutaneous Balloon Compression Surgery in Patients with Trigeminal Neuralgia
10.3969/j.issn.1671-7414.2025.02.034
- VernacularTitle:三叉神经痛患者血清神经元特异性烯醇化酶水平与行经皮球囊压迫术后复发的相关性研究
- Author:
Liang QI
1
;
Wenguang LIU
1
;
Jinyu ZHENG
1
;
Huanhuan JI
1
Author Information
1. 淮安市第二人民医院/徐州医科大学附属淮安医院,江苏 淮安 223000
- Publication Type:Journal Article
- Keywords:
neuron-specific enolase;
trigeminal neuralgia;
percutaneous balloon compression
- From:
Journal of Modern Laboratory Medicine
2025;40(2):180-185
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between neuron specific enolase(NSE)levels and recurrence after percutaneous balloon compression(PBC)in patients with trigeminal neuralgia(TN).Methods 166 TN patients who underwent PBC at the Second People's Hospital of Huai'an City,Jiangsu Province from July 2018 to April 2021 were selected as the study subjects.According to the recurrence rate after 2 years of surgery,patients were divided into a recurrence group(n=22)and a non-recurrence group(n=144).The general information of the two groups of patients was compared,and the serum biomarker levels before and after PBC in TN patients were analyzed,as well as the postoperative efficacy of TN patients with PBC.Compared the difference changes(T2-T1)between various inflammatory markers and nerve injury markers before surgery(T1)and 2 days after surgery(T2),and perform correlation analysis(Spearman correlation and Logistic regression)between the significantly changed difference indicators and prognosis recurrence to explor the predictive value of serum NSE for recurrence after PBC in TN patients.Results The serum NSE level of TN patients on the first day of PBC was 12.39±3.15 ng/ml,were compored with those on the second day after PBC was 16.27±4.03ng/ml,and the difference was statisically significant(t=14.922,P<0.01).The difference in serum NEC levels before and after PBC in the recurrent group was 5.72(5.25,7.58)ng/ml,while the difference in serum NSE levels before and after PBC in the non-recurrent group was 3.01(2.63,3.37)ng/ml,the difference between the two groups was statistically significant(Z=3.925,P<0.001).Logistic regression results showed that the difference in serum NSE levels(T2-T1)before and after PBC was a rish factor for postoperative recurrence in TN patients at two-years(OR=1.602,Wald χ2=12.252,P<0.05).ROC analysis tesults:the predictive power of serum NSE difference(T2-T1)before and after PBC for two-year recurrence in TN patients AUC(95%CI)was 0.777(0.587～0.954),and the prediction threshold was 4ng/ml.The corresponding sensitivity and specificity was 0.727 and 0.806,respectively.Conclusion Serum NSE may become a biomarker for predicting the recurrence of TN patients after PBC treatment.
