Study on the Correlation between Serum Proprotein Convertase Subtilisin/Kexin Type 9 and Glucose and Lipid Metabolism and Insulin Resistance in Patients with Polycystic Ovary Syndrome
10.3969/j.issn.1671-7414.2025.02.029
- VernacularTitle:多囊卵巢综合征患者血清前蛋白转化酶枯草溶菌素9表达水平与糖脂代谢及胰岛素抵抗的相关性研究
- Author:
Xiaoli GUO
1
;
Jing HUI
;
Hui HUI
Author Information
1. 延安市人民医院 妇产科一病区,陕西 延安 716000
- Publication Type:Journal Article
- Keywords:
polycystic ovary syndrome;
proprotein convertase subtilisin/kexin type 9;
insulin resistance;
glucose and lipid metabolism
- From:
Journal of Modern Laboratory Medicine
2025;40(2):156-159
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum proprotein convertase subtilisin/kexin type 9(PCSK9)and glucose and lipid metabolism and insulin resistance(IR)in patients with polycystic ovary syndrome(PCOS).Methods 154 newly diagnosed PCOS patients admitted to Yan'an People's Hospital from June 2019 to August 2021 were selected as the PCOS group.The homeostasis model assessment of insulin resistance index(HOMA-IR)of patients,those with HOMA-IR<2.69 were included in the non IR group(n=62),and those with HOMA-IR≥2.69 were included in the IR group(n=92).Another 50 healthy volunteers with normal physical examination results were selected as the control group.The level of serum PCSK9 was detected by ELISA kit.The sex hormone indexes and glucose lipid metabolism indexes of all subjects were compared.The relationship between serum PCSK9,glucose and lipid metabolism indexes,and sex hormone indexes in PCOS patients were analyzed by Pearson correlation.The factors influencing IR in PCOS patients were analyzed using binary logistics regression.Results Serum PCSK9 in PCOS group(292.57±42.31 ng/ml)was higher than that in control group(226.94±20.18 ng/ml),the difference was statistically significant(t=10.379,P<0.001).Serum PCSK9 in IR group(324.51±50.33 ng/ml)was higher than that in non-IR group(245.18±40.16 ng/ml),the difference was statistically significant(t=10.379,P<0.001).Pearson analysis showed that serum PCSK9 of PCOS patients was positively correlated with LH,fasting blood glucose,fasting insulin,HOMA-IR,LDL-C,total cholesterol,and triglyceride(r=0.302～0.684,all P<0.05).Multivariate Logsitic regression analysis showed that fasting blood glucose,fasting insulin and serum PCSK9 were the influencing factors of IR in PCOS patients(Wald χ2=8.501,8.024,7.886,all P＜0.05).Conclusion PCSK9 is abnormally high expressed in serum of PCOS patients,and its expression level is closely related to the glucose and lipid metabolism and IR status of patients.
