Relationship between Serum HE4,CEA,CA199 Levels with Clinicopathological Characteristics and Prognosis of Uterine Fibroid Patients
10.13241/j.cnki.pmb.2025.11.010
- VernacularTitle:血清HE4、CEA、CA199水平与子宫肌瘤患者临床病理特征及预后的关系
- Author:
Hai-ping DAI
1
;
Chen-chen YAO
;
Hai-jie GAO
;
Li-juan WANG
Author Information
1. 厦门大学附属妇女儿童医院(厦门市妇幼保健院)病理科 福建厦门 361003
- Publication Type:Journal Article
- Keywords:
Uterine fibroid;
Human epididymal secretory potein 4;
Carcinoembryonic antigen;
Carbohydrate antigen 199;
Clinicopathological characteristics;
Prognosis
- From:
Progress in Modern Biomedicine
2025;25(11):1838-1846
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between serum human epididymal secretory potein 4(HE4),carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199)levels with clinicopathological characteristics and prognosis of uterine fibroid patients.Methods:87 patients who were diagnosed with uterine fibroids in Xiamen Maternal and Child Health Hospital during the period of January 2019 to January 2024 were selected as the observation group,and 87 women who underwent health checkups during the same period were selected as the control group.The serum HE4,CEA and CA199 levels were detected and compared between the two groups before and 1 month after surgery.The relationship between serum HE4,CEA and CA199 levels before surgery and their clinicopathological characteristics was analyzed.The patients with uterine fibroids were followed up for 1 year after surgery,and they were divided into recurrence group and non-recurrence group according to the recurrence status,influencing factors of postoperative recurrence were analyzed by multiple logistic regression model,the predictive value of CEA,HE4,and CA199 for postoperative recurrence was analyzed by receiver operating characteristic(ROC)curves.Results:Serum HE4,CEA and CA199 levels before surgery in the observation group were significantly higher than those in the control group(P＜0.05).Serum HE4,CEA and CA199 levels before surgery in uterine fibroids patients were significantly correlated with breast hyperplasia,the location of the fibroids,the number of tumors and the maximum diameter of the fibroids(P＜0.05).87 patients with uterine fibroids were followed up for 1 year after surgery,with a recurrence rate of 26.44％.Serum HE4,CEA and CA199 levels at 1 month after surgery in the recurrence group were significantly higher than those in the non-recurrence group(P＜0.05).Elevated HE4,elevated CEA and elevatedCA199 were independent risk factors for postoperative recurrence in uterine fibroids patients(P＜0.05).The area under the curve(AUC)of combined prediction of CEA,HE4,and CA199 for predicting postoperative recurrence of uterine fibroma patients was 0.880.Conclusion:Serum HE4,CEA,and CA199 in uterine fibroids patients are abnormally elevated,and closely related to their clinicopathological characteristics.Serum HE4,CEA,and CA199 levles are influencing factors for postoperative recurrence in uterine fibroids patients and have good predictive value for postoperative recurrence.
