SAS macro tool for pharmacokinetic parameter estimation based on non-compartmental models
10.12092/j.issn.1009-2501.2025.05.004
- VernacularTitle:基于非房室模型的药代动力学参数计算SAS宏工具
- Author:
Li ZHANG
1
;
Donghua LOU
1
Author Information
1. 南京医科大学公共卫生学院,南京 211166,江苏
- Publication Type:Journal Article
- Keywords:
non-compartmental analysis(NCA);
SAS macros;
PK parameters
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(5):608-621
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To develop a SAS macro tool for calculating pharmacokinetic(PK)parameters using non-compartmental analysis(NCA)that is applica-ble to various routes and frequencies of drug ad-ministration.METHODS:By incorporating the prin-ciples of NCA PK parameter calculations,the struc-ture of the SAS macro program is designed and pro-grammed.The usage of the macro program is dem-onstrated through simulated examples.RESULTS:Based on NCA,this study programmed a SAS macro using SAS macro language to calculate both single-dose and steady-state complete PK parameters.It supports three modes of drug administration:ex-travascular,intravenous infusion,and intravenous bolus injection,as well as four algorithms for calcu-lating area under the curve(AUC).By comparing with authoritative calculation software,the results were found to be highly consistent across various calculation scenarios,with more accurate calcula-tions for the time of first measurable concentration(Tlag).CONCLUSION:The％M_CREATE_PK_PARAM-ETERS macro is a SAS macro that supports compre-hensive PK parameter calculations in NCA,provid-ing an accurate,efficient,and flexible solution for PK parameter estimation with broad application prospects.
