Risk analysis of allergy to ketoconazole shampoo and selenium sulfide shampoo in patients with androgenetic alopecia
- VernacularTitle:雄激素性秃发患者对酮康唑洗剂和二硫化硒洗剂过敏风险分析
- Author:
Ying WANG
1
;
Dingquan YANG
1
Author Information
- Publication Type:Journal Article
- Keywords: alopecia; dermatitis,seborrheic; disulfides; selenium; ketoconazole; dermatitis,contact
- From: Tianjin Medical Journal 2025;53(6):670-672
- CountryChina
- Language:Chinese
- Abstract: Objective To analyze the incidence of contact allergic reactions to ketoconazole shampoo and selenium sulfide shampoo in patients with androgenetic alopecia(AGA).Methods A retrospective analysis was conducted on 683 AGA patients.Based on medical records,dermoscopy findings,fungal examinations and patch test results,the number of patients with seborrheic dermatitis,Malassezia-positive cases and contact allergy to ketoconazole and selenium sulfide shampoos were recorded.Results The incidence of seborrheic dermatitis in AGA patients was 65.59%,and the Malassezia-positive rate was 42.02%.The allergy rate to ketoconazole shampoo in AGA patients was 34.70%,which was significantly higher than the 25.62%allergy rate to selenium sulfide shampoo(P＜0.01).In AGA patients with concomitant seborrheic dermatitis and Malassezia positivity,the allergy rate to ketoconazole lotion was higher than that to selenium sulfide lotion(P＜0.05).The positivity rate of Malassezia was 45.98%in seborrheic dermatitis patients,which was higher than that of the 34.47%in non-seborrheic dermatitis patients(P＜0.01).Conclusion In patients with AGA,ketoconazole shampoo carries a higher allergy risk compared to selenium sulfide shampoo.Long-term use of antifungal shampoos should be avoided in patients with AGA and conduct patch tests for drug detection when necessary.
