The effect of continuous positive airway pressure ventilation on mean airway pressure and neurological function in stroke patients with obstructive sleep apnea syndrome
- VernacularTitle:持续气道正压通气对合并阻塞性睡眠呼吸暂停综合征的脑梗死患者平均气道压及神经功能的影响
- Author:
Jianbo JIA
1
;
Gen SUN
;
Yuanyuan GU
Author Information
- Publication Type:Journal Article
- Keywords: continuous positive airway pressure; sleep apnea,obstructive; brain infarction; mean airway pressure; neurological function
- From: Tianjin Medical Journal 2025;53(6):639-643
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the effects of continuous positive airway pressure(CPAP)on mean airway pressure and neurological function in cerebral infarction patients with obstructive sleep apnea-hypopnea syndrome(OSAS).Methods A total of 245 patients with cerebral infarction complicated with OSAS(who received treatment in our hospital from February 2020 to October 2023)were collected and studied by prospective study.Among them,152 patients received basic intervention measures such as conventional drugs and rehabilitation therapy,and 93 patients received CPAP therapy on the basis of basic intervention measures.Matching according to 1∶1 propensity score matching method,48 cases were divided into the control group and 48 cases were used as the observation group.The treatment period of the two groups was 14 days.Before treatment and after 14 days of treatment,the oxygen desaturation index(ODI),lowest oxygen saturation(LSaO2),respiratory mechanics indexes[airway resistance(Raw),mean airway pressure(MPaw)and peak inspiratory pressure(PIP)],neurological function scores[National Institutes of Health Stroke Scale(NIHSS)score,modified Rankina scale(mRS)score after 3 months]and Barthel index(BI)score were compared between the two groups,and the efficacy and the occurrence of adverse reactions were evaluated.Results After 14 days of treatment,the ODI,respiratory mechanics indexes Raw,MPaw,PIP,NIHSS score and mRS score were greatly reduced in the two groups,however,LSaO2 and BI score was increased(P＜0.05).The ODI,Raw,MPaw,PIP,NIHSS score and mRS score were lower in the observation group than those of the control group,while LSaO2 and BI score were higher in the observation group than those of the control group(P＜0.05).The total effective rate of the observation group was higher than that of the control group(87.5%vs.68.8%,P=0.026).There was no significant difference in the incidence of adverse reactions between the two groups(P=0.673).Conclusion CPAP is beneficial for reducing MPaw,improving oxygen saturation and neurological function,and increasing total effective rate in patients with cerebral infarction combined with OSAS.It can be widely applied in clinical practice.
