Research advances of oxygen-sensing signaling pathway in rheumatoid arthritis pathogenesis
10.3969/j.issn.1000-484X.2025.03.036
- VernacularTitle:氧感知信号通路在类风湿关节炎中的研究进展
- Author:
Xiaoman LIU
1
;
Xiaolan SHEN
;
Xiang GUO
;
Jingkai ZHANG
;
Xiaoqiang HOU
;
Zhitao FENG
Author Information
1. 三峡大学健康医学院,宜昌 443002
- Publication Type:Journal Article
- Keywords:
Oxygen sense;
Rheumatoid arthritis;
Hypoxia inducible factor;
Signal pathway;
Angiogenes
- From:
Chinese Journal of Immunology
2025;41(3):714-720
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis(RA)is an autoimmune disease characterized by synovitis,synovial cell proliferation,neo-vascularization,and bone and cartilage destruction.Its pathogenesis is complex and has not yet been fully elucidated.A variety of cells,cytokines and signaling pathways are involved in the pathogenesis of RA.Hypoxia-inducing factor(HIF)and oxygen-sensing signaling pathway(PHD-HIF-VHL)are closely related to the occurrence and development of RA,and play an important role in syno-vial cell proliferation,inflammatory response and cartilage destruction.In this study,the research progress of oxygen sensing signaling pathway in RA was described from the aspects of the mechanism of oxygen sensing signaling pathway and its involvement in the patho-genesis of RA,in order to provide ideas and theoretical basis for the research of anti-RA drugs by targeting important molecules of oxy-gen sensing signaling pathway.
