Research progress on regulation of inflammatory response by glucose metabolic reprogramming
10.3969/j.issn.1000-484X.2025.03.035
- VernacularTitle:糖代谢重编程调控炎症反应的研究进展
- Author:
Tinglyu FU
1
;
Rui XIONG
1
;
Ning LI
1
;
Qing GENG
1
Author Information
1. 武汉大学人民医院胸外科,武汉 430060
- Publication Type:Journal Article
- Keywords:
Glucose metabolic reprogramming;
Inflammatory response;
Metabolic intermediates;
Epigenetic regulation;
Post-transcriptional regulation;
Post-translational modification
- From:
Chinese Journal of Immunology
2025;41(3):709-713
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory response is a common feature of many acute and chronic diseases,which involves in activation of various cell types.Similar to tumor cells,inflammatory response is regulated by glucose metabolic reprogramming.Cells involved in pro-inflammatory response,such as M1 macrophages,Th1 and Th17 lymphocytes,must generate energy rapidly through glycolysis transformed by glucose metabolic reprogramming to promote inflammation,while cells involved in immune regulation and anti-inflam-matory response,such as regulatory T cells and M2 macrophages,preferentially use fatty acid oxidation and oxidative phosphorylation as a main source for energy production.This article systematically reviews the role of glucose metabolic reprogramming in different stages of inflammatory response,as well as the various molecular mechanisms of glucose metabolic reprogramming in inflammatory response,including activation or inhibition of signaling pathways,epigenetic regulation,post-transcriptional regulation and post-translational modification,which aims to provide a reference for exploring the specific regulatory mechanisms of glucose metabolic reprogramming on inflammatory response and the therapeutic targets of inflammatory-related diseases.
