Correlation between TWEAK,KIM-1,RPR and disease activity,renal injury in children with systemic lupus erythematosus
10.3969/j.issn.1000-484X.2025.03.028
- VernacularTitle:TWEAK、KIM-1及RPR与系统性红斑狼疮患儿疾病活动程度、肾损伤的相关性分析
- Author:
Shen ZHAO
1
;
Junjie LI
1
Author Information
1. 湖北文理学院附属襄阳市中心医院儿科,襄阳 441000
- Publication Type:Journal Article
- Keywords:
Systemic lupus erythematosus;
Tumor necrosis factor-like weak inducer of apoptosis;
Kidney injury molecule 1;
RBC distribution width/platelet ratio;
Disease activity;
Lupus nephritis
- From:
Chinese Journal of Immunology
2025;41(3):675-679
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between tumor necrosis factor-like weak inducer of apoptosis(TWEAK),kidney injury molecule 1(KIM-1),RBC distribution width/platelet ratio(RPR)and disease activity,renal injury in children with sys-temic lupus erythematosus(SLE).Methods:A total of 42 children with newly diagnosed SLE in Xiangyang Central Hospital were en-rolled as SLE group between February 2020 and February 2022,while another 40 healthy children undergoing physical examination during the same period were enrolled as control group.According to scores of systemic lupus erythematosus disease activity index(SLEDAI),SLE children were divided into low disease activity group(≤9 points)24 cases and high disease activity group(>9 points)18 cases.According to presence or absence of renal injury,SLE children were divided into LN group 31 cases and non-LN group 11 cases.The red blood cell distribution width(RDW)and platelet count(PLT)in all objects were detected.RPR was calculated.The levels of serum TWEAK and KIM-1 were detected by ELISA.Results:The levels of serum TWEAK,KIM-1 and RPR in SLE group were significantly higher than those in control group(P<0.05).The levels of serum TWEAK,KIM-1 and RPR in high disease activity group were significantly higher than those in low disease activity group(P<0.05),which were significantly higher in LN group than non-LN group(P<0.05).Correlation analysis showed that RPR was significantly positively correlated with SLEDAI score(P<0.05),TWEAK and KIM-1 were significantly positively correlated with 24 h urinary protein(P<0.05).AUC of RPR for assessing high disease activity of SLE was 0.744(95%CI:0.657～0.818),significantly greater than that of TWEAK and KIM-1[0.678(95%CI:0.588～0.760),0.598(95%CI:0.505～0.686),P<0.05].AUC values of TWEAK and KIM-1 for predicting LN 0.847(95%CI:0.773～0.905)and 0.773(95%CI:0.690～0.842),significantly greater than that of RPR AUC values[0.645(95%CI:0.555～0.727),P<0.05].Conclusion:The levels of TWEAK,KIM-1 and RPR are changed in children with SLE.RPR has higher diagnostic efficiency for SLE activity,while TWEAK and KIM-1 have higher predictive value for LN.
