Study on changes of type 2 intrinsic lymphocyte(ILC2)in Brucella infection
10.3969/j.issn.1000-484X.2025.03.025
- VernacularTitle:2型固有淋巴细胞(ILC2)在布鲁氏菌感染中的变化特点研究
- Author:
Zhengwei YIN
1
;
Yuejie ZHU
;
Juan SHI
;
Yueyue HE
;
Jianbing DING
;
Quan WANG
;
Fengbo ZHANG
Author Information
1. 省部共建中亚高发病成因与防治国家重点实验室,新疆医科大学第一附属医院,乌鲁木齐 830011
- Publication Type:Journal Article
- Keywords:
Brucella infection;
Type 2 intrinsic lymphocyte;
GATA3;
IL-33;
IL-4;
IL-13
- From:
Chinese Journal of Immunology
2025;41(3):655-660
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate variation and correlation of type 2 intrinsic lymphocyte(ILC2)and related factors in acute and chronic brucellosis,to identify immune role of ILC2 in chronic brucellosis.Methods:Forty-three patients with acute brucel-losis and 45 patients with chronic brucellosis were compared with 49 healthy controls.ILC2 level in each group was detected by flow cytometry.mRNA level of GATA3 in PBMC was detected by fluorescence quantitative PCR.Serum IL-33,ST2,IL-4 and IL-13 levels were detected by ELISA.ALT and AST levels were measured by fully automatic biochemical analyzer.Results:ILC2 level,GATA3 mRNA in PBMC,serum IL-33,IL-4 and IL-13 levels in chronic brucellosis group were significantly higher than healthy control group and acute brucellosis group(P<0.01).Correlation analysis showed that ILC2 level was positively correlated with GATA3 mRNA,IL-33,IL-4 and IL-13 levels,while negatively correlated with ST2 level.ROC curve suggested that ILC2,GATA3,IL-33 and ST2 had good predictive ability for severity of brucellosis patients(AUC>0.7).Conclusion:Increase of ILC2 and its related factors are closely related to chronic brucella infection,which may play an important immune role in pathogenesis of brucella infection.
