Dynamic phase transition mechanism of stress granules after ischemic stroke and its impact on neurons
10.3969/j.issn.1672-5921.2025.05.010
- VernacularTitle:缺血性卒中后应激颗粒动态相变机制及其对神经元的影响
- Author:
Qing ZHU
1
;
Xianglong ZHAI
1
;
Beibei YAO
1
;
Zhaoyao CHEN
1
;
Wenlei LI
1
;
Yuan ZHU
1
;
Minghua WU
1
Author Information
1. 210029 南京中医药大学附属医院神经内科
- Publication Type:Journal Article
- Keywords:
Ischemic stroke;
Neurons;
Phase transition;
Stress granules;
Review
- From:
Chinese Journal of Cerebrovascular Diseases
2025;22(5):356-362
- CountryChina
- Language:Chinese
-
Abstract:
During the progression of ischemic stroke,cells experience oxidative stress and intracellular energy depletion,triggering the dynamic assembly and disassembly of stress granules.Stress granules may have a dual role in ischemic stroke.In the ultra-early reperfusion period(6-36 h),under acute stress,the stress granules may inhibit neuronal apoptosis and exert neuroprotective effects through reversible liquid-liquid phase separation.In contrast,in the acute reperfusion period(36 h to 2 weeks),under prolonged stress,pathological stress granules may accumulate through liquid-solid phase transition,leading to neuronal dysfunction and inducing ischemic stroke sequelae such as motor and cognitive impairments.This article reviewed the mechanisms of stress granules dynamic phase transitions during ischemic stroke and their effects on neurons,aiming to provide references and insights for future stress granule-targeted interventions for ischemic stroke and its sequelae.
