Progress in treatment of anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis
- VernacularTitle:抗黑色素瘤分化相关基因5抗体阳性皮肌炎治疗进展
- Author:
Jinshan ZHAN
1
;
Xiuyun XUAN
1
;
Juanmei CAO
1
;
Fangqi CHEN
1
;
Changzheng HUANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Dermatomyositis; Immunosuppressive therapy; Melanoma differentiation-associated gene 5; Anti-melanoma differentiation-associated gene 5 antibody; Intersti
- From: Chinese Journal of Dermatology 2025;58(8):785-788
- CountryChina
- Language:Chinese
- Abstract: Anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis is a special type of dermatomyositis. It has characteristic clinical manifestations, mild myositis symptoms, and is prone to be accompanied by rapidly progressive interstitial lung disease, which indicates a poor prognosis. Its pathogenesis remains unclear, and may be related to genetic and environmental factors. This review summarizes progress in the treatment of anti-MDA5 antibody-positive dermatomyositis in recent years, in order to provide new ideas for its clinical treatment.
