Symptoms and quality of life benefits of successful percutaneous coronary intervention in left main disease and/or 3-vessel disease patients with diabetes
10.3969/j.issn.1004-8812.2025.02.005
- VernacularTitle:糖尿病合并左主干病变和(或)三支血管病变患者成功的经皮冠状动脉介入治疗对症状和生活质量的益处
- Author:
Bo-da ZHU
1
;
Tian-tong YU
;
Peng HAN
;
Bo-hui ZHANG
;
Xi ZHANG
;
Ping YUAN
;
Gang WANG
;
Yi YANG
;
Hui-li ZHU
;
Pan-pan SUN
;
Tong-tong LI
;
Shuai ZHAO
;
Cheng-xiang LI
;
Kun LIAN
Author Information
1. 中国人民解放军空军军医大学第一附属医院心血管内科,陕西西安 710032;空军航空大学初级飞行训练基地,黑龙江哈尔滨 150100
- Publication Type:Journal Article
- Keywords:
Left main disease;
3-vessel disease;
Diabetes;
Symptoms;
Quality of life
- From:
Chinese Journal of Interventional Cardiology
2025;33(2):93-100
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether successful percutaneous coronary intervention(PCI)could improve symptoms and quality of life(QOL)in left main disease and/or 3-vessel disease patients with diabetes.Methods Patients with left main disease and/or 3-vessel disease who underwent PCI in the First Affiliated Hospital of Air Force Medical University from April 2018 to May 2021 were consecutively enrolled and subdivided into 2 groups:diabetes and no diabetes.Detailed baseline characteristics,symptoms,including dyspnea and angina,assessed with the Rose dyspnea scale(RDS),Seattle angina questionnaire(SAQ),the European quality of life-5 dimensions(EQ-5D)and 12-item short-form health survey(SF-12)questionnaire respectively,procedural details,and 1 month and 1 year follow-up data were collected.Results Among 440 left main disease and/or 3-vessel disease patients,disease was present in 176(40.00％),who had more hypertension,peripheral artery disease,and LCX lesion(all P＜0.05).The incidence of major adverse cardiovascular events(MACE)and all-cause mortality were similar between the two groups(both P＞0.05)at 1 month follow-up,while all-cause mortality in diabetes patients was significantly higher than those without diabetes at 1 year follow-up(P=0.013).Low left ventricular ejection fraction was an independent risk factor for MACE and all-cause mortality at 1 month and 1 year follow-up after successful revascularization(all P＜0.05).Most importantly,symptoms,including dyspnea and angina,and QOL were markedly improved regardless of diabetes both at 1 month and 1 year follow-up(all P＜0.05).Diabetes patients showed improved dyspnea and QOL at similar degree to the non-diabetes patients(all P＞0.05)and a more significantly relieved angina(P=0.013).Additionally,the number of chronic total occlusion(CTO)per patient was identified as an independent risk factor of dyspnea(OR 0.723,95％CI 0.525～0.997,P=0.048)and angina relief(OR 0.686,95％CI 0.473～0.995,P=0.047),and the contrast volume(OR 0.995,95％CI 0.992～0.999,P=0.008)as an independent risk factor of QOL improvement in diabetic patients.Conclusions Successful PCI is beneficial for relieving symptoms and improving quality of life in patients with diabetes who have left main disease and/or 3-vessel disease.
