Low-dose helical CT coronary calcification score has predictive value for the severity of coronary artery and prognosis in patients with unstable angina pectoris
10.3969/j.issn.1004-8812.2025.02.004
- VernacularTitle:低剂量螺旋CT冠状动脉钙化积分对不稳定型心绞痛患者冠状动脉病变及预后的预测价值
- Author:
Chun-yan WANG
1
;
Jian-hui LI
;
Fang-fang FAN
;
He WANG
Author Information
1. 北京大学第一医院心内科,北京 100034
- Publication Type:Journal Article
- Keywords:
Low-dose helical CT;
Coronary artery calcification score;
Coronary angiography;
Three-vessel coronary artery disease;
Prognosis
- From:
Chinese Journal of Interventional Cardiology
2025;33(2):87-92
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the predictive value of coronary artery calcification score on low-dose helical CT(LDCT)in patients with unstable angina pectoris.Methods One hundred thirty-two patients with unstable angina who underwent LDCT and coronary angiography(CAG)were retrospectively analyzed.Clinical characteristics,calcification scores,and CAG findings were recorded.Patients underwent follow-up to record the occurrence of major adverse cardiovascular events(MACE).Univariate and multivariate analyses were performed to determine the relationship between calcification score and severity of disease.Results(1)LDCT calcification score significantly differed between the no-vessel disease,single-vessel disease,two-vessel disease,and three-vessel disease groups(P=0.001).LDCT calcification score was associated with three-vessel disease on CAG.For each 100-point increase in LDCT calcification score,the probability of three-vessel disease increased by 12％(95％CI 1.04-1.20,P=0.003).Compared with patients with mild calcification(score＜100 Agatston units),patients with moderate(score 100-399 Agatston units)and severe(score≥400 Agatston units)calcification were 3.69 times(95％CI 1.27-10.76,P=0.017)and 5.48 times(95％CI 1.87-16.02,P=0.002)more likely to have three-vessel disease,respectively.(2)Patients with LDCT calcification score≥ 196.05 Agatston units were more likely to have three-vessel disease.The sensitivity,specificity,and accuracy of LDCT calcification score≥ 196.05 Agatston units for diagnosing three-vessel coronary artery disease was 0.72,0.65,and 0.67,respectively;the area under the receiver operating characteristic curve was 0.699.(3)The odds of coronary revascularization during follow-up were 8.23 times(95％CI 1.12-60.67,P=0.039)higher in patients with severe calcification than in those without it.Conclusions LDCT can predict CAD in patients with unstable angina,especially severe disease,and is related to MACE.
