Advances in study of poliovirus receptor family in hematological tumors
10.3969/j.issn.1000-484X.2025.06.043
- VernacularTitle:脊髓灰质炎病毒受体家族在血液肿瘤中的研究进展
- Author:
Qian LEI
1
;
Lijuan LI
1
;
Xiaoli MA
1
;
Liansheng ZHANG
1
Author Information
1. 兰州大学第二医院血液科,兰州 730030
- Publication Type:Journal Article
- Keywords:
PVR;
TIGIT;
Hematological tumors;
Immunotherapy
- From:
Chinese Journal of Immunology
2025;41(6):1523-1530,中插6-中插8
- CountryChina
- Language:Chinese
-
Abstract:
Poliovirus receptor(PVR)family includes several immune checkpoint receptors such as T cell immunoglobulin and immunoreceptor tyrosine-based inhibition motif structural domains(TIGIT),CD96 and CD226,and their ligands CD155 and CD112,etc.PVR family members have sequence homology and highly interact with each other for synergistic stimulatory or inhibitory effects,forming a complex immunomodulatory network together.The co-signaling network formed by PVR family members is of great significance and has become a major hot spot in hematologic tumor immunotherapy in recent years.This review describes the structure of PVR family members,their mechanism of action,research progress in hematological tumors,and their prospects for application in the immunotherapy of hematologic tumors.
