Research progress of basic helix-loop-helix E40 in immune cells
10.3969/j.issn.1000-484X.2025.06.041
- VernacularTitle:基本螺旋-环-螺旋家族成员E40在免疫细胞中的研究进展
- Author:
Zhenjie LUO
1
;
Dengrong ZHANG
;
Chunyao LIU
;
Ling GAO
;
Xianping LONG
;
Song WANG
Author Information
1. 遵义医科大学附属医院急诊科,遵义 563000
- Publication Type:Journal Article
- Keywords:
Basic helix-loop-helix E40;
Activation of immune cell;
Cell cycle;
Self-renewal;
Cytokine
- From:
Chinese Journal of Immunology
2025;41(6):1512-1516
- CountryChina
- Language:Chinese
-
Abstract:
Immune cells are formed by the proliferation and differentiation of hematopoietic stem cells in the bone marrow,in-cluding lymphocytes,macrophages,etc,which participate in the immune defense,immune stability and immune monitoring of the body,and are an indispensable basic component of the immune system.Basic helix-loop-helix family member E40(BHLHE40)has been shown to play an important role in adipogenesis,tumorigenesis,circadian rhythm and hypoxia response.Recently,it was found that BHLHE40 plays a key role in the cell cycle,proliferation and cytokine production of immune cells.This article will review the discovery,naming,structure,and mechanism of BHLHE40 in various periods,as well as it's research progress in immune cells,in order to provide new target for the treatment of immune-related diseases at the genetic level.
