The application of metagenomic next-generation sequencing successfully prevented organ donation from a deceased donor infected with rabies virus : a case report

VernacularTitle:因mNGS诊断狂犬病毒感染终止遗体器官捐献1例
Author: Chao LI ¹ ; Xin YE ¹ ; Wenqing GE ¹ ; Zheng ZHOU ¹ ; Liangliang WANG ¹
Author Information

1. 苏州大学附属第一医院泌尿外科，苏州　215006
Publication Type:Journal Article
Keywords: Organ donation; Next-generation sequencing; Rabies virus; Myocarditis
From: Chinese Journal of Organ Transplantation 2025;46(8):610-612
CountryChina
Language:Chinese
Abstract: Metagenomic next-generation sequencing (mNGS) has emerged as a pivotal tool in the detection and characterization of infectious pathogens in clinical settings, and it has been applied to donor assessment. This case report describes the effective application of mNGS in preventing the transplantation of organs from a donor infected with the rabies virus, who presented with myocarditis. The rapid and accurate identification of the rabies virus through mNGS potentially averted the risk of transmission to organ recipients.