Research progress on PANoptosis in ischemia-reperfusion injury of liver transplantation
10.3760/cma.j.cn421203-20241030-00221
- VernacularTitle:细胞泛死亡及相互串扰在肝移植缺血再灌注损伤中的研究进展
- Author:
Weigao PU
1
;
Jianming SHI
;
Liyang CHENG
;
Bo XU
;
Yunpeng WANG
;
Guodong SUN
;
Jike HU
;
Hao CHEN
Author Information
1. 兰州大学第二医院（第二临床医学院），兰州 730030
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Ischemia-reperfusion injury;
PANoptosis;
Apoptosis;
Pyroptosis;
Necroptosis;
Ferroptosis
- From:
Chinese Journal of Organ Transplantation
2025;46(7):530-537
- CountryChina
- Language:Chinese
-
Abstract:
Liver transplantation is the preferred treatment for cirrhosis, end-stage liver failure, and hepatocellular carcinoma, and is also the only effective curative method. Liver ischemia-reperfusion injury (IRI) is one of the main adverse reactions of liver transplantation. During the operation, ischemia mediates the occurrence of liver IRI, promoting the cascade activation of reactive oxygen species and pro-inflammatory signals in Kupffer cells. With continued hepatocellular death during ischemia, damage-associated molecular patterns (DAMPs) accumulate and are released into systemic circulation, triggering a cytokine and chemokine storm, resulting in poor prognosis, postoperative liver failure, systemic inflammatory response syndrome (SIRS), and multiple organ dysfunction syndrome (MODS). In liver transplantation-related IRI, PANoptosis—including apoptosis, pyroptosis, necroptosis, ferroptosis, and autophagy—participates in the process, but a comprehensive review is lacking. This article systematically elaborates on the roles of different types of cell death in liver IRI and the crosstalk among these pathways. It also discusses the protective effects of inhibiting different forms of cell death, aiming to provide direction for future basic research and offer new ideas and strategies for the clinical treatment of liver IRI.
