Establishment and evaluation of a prognostic model for ovarian cancer based on PD-1 and B lymphocyte infiltration
10.3969/j.issn.1000-484X.2025.06.030
- VernacularTitle:基于PD-1和B淋巴细胞浸润的卵巢癌预后模型建立与评价
- Author:
Wei XIE
1
;
Xiaoyan LIU
1
;
Wenling HAN
1
;
Yuan FANG
1
Author Information
1. 赣南医学院第一附属医院,赣州 341000
- Publication Type:Journal Article
- Keywords:
Programmed cell death protein-1;
Ovarian cancer;
Relevance;
B lymphocyte infiltration
- From:
Chinese Journal of Immunology
2025;41(6):1440-1446
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To construct a prognostic model for ovarian cancer based on programmed cell death receptor-1(PD-1)and B lymphocyte infiltration.Methods:A total of 102 patients with ovarian cancer admitted to the First Affiliated Hospital of Gannan Medical College from February 2019 to February 2022 were selected.PD-1 expression and CD20+B cell infiltration degree in cancer tissues were detected,relationship between them and pathological characteristics were analyzed,and correlation between PD-1 expres-sion with B lymphocyte infiltration degree and survival rate of patients were analyzed.Independent influencing factors of poor prognosis of ovarian cancer patients were analyzed,prediction model was built and validated according to independent factors.Results:PD-1 expression and CD20+B cell infiltration degree were closely related to tumor size,FIGO stage,tumor differentiation and lymph node metastasis(P<0.05).PD-1 expression was negatively correlated with B-lymphocyte infiltration degree(P<0.05).Patients with high PD-1 expression and low B-lymphocyte infiltration had higher mortality(P<0.05).FIGO stage,lymph node metastasis,PD-1 expres-sion and CD20+B cell infiltration were independent factors affecting poor prognosis of ovarian cancer patients.Prediction model was constructed by independent influencing factors,which had good differentiation and accuracy.Conclusion:PD-1 expression is closely related to CD20+B cell infiltration degree.There is a close relationship between PD-1 and CD20+B cell infiltration with clinico-pathological characteristics and prognosis of ovarian cancer patients,which are independent influencing factors for poor prognosis of ovarian cancer patients.
