Recent Progress of the Pathogenesis of Cancer-Related Fatigue and Chinese Medicine Intervention
10.14148/j.issn.1672-0482.2025.0838
- VernacularTitle:癌因性疲乏发病机制及中医药干预研究进展
- Author:
Shuxian YANG
1
;
Yu HONG
;
Lijuan CAO
Author Information
1. 中国药科大学多靶标天然药物全国重点实验室,江苏 南京 210009
- Publication Type:Journal Article
- Keywords:
cancer-related fatigue;
pathogenesis;
traditional Chinese medicine
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2025;41(6):838-846
- CountryChina
- Language:Chinese
-
Abstract:
Cancer-related fatigue(CRF)is an adverse symptom associated with cancer and its treatments,with a clinical inci-dence rate ranging from 60%to 90%,severely impacting patients'quality of life.The pathogenesis of CRF is complex,involving the interaction of multiple mechanisms such as inflammatory cytokine dysregulation,neuroendocrine disorders,and mitochondrial dysfunc-tion.Although existing clinical interventions like central nervous system stimulants and exercise interventions can partially alleviate symptoms,they are limited by side effects and applicability constraints.Traditional Chinese medicine(TCM)shows unique potential in the clinical treatment of CRF by exerting a variety of pharmacological effects.Therapeutic approaches including acupuncture,moxibus-tion,traditional Chinese herbal formulations,as well as Chinese herbal preparations and extracts,have been proven to significantly im-prove fatigue status in CRF patients.This article systematically reviews the internal relationship between the modern pathological mech-anism of CRF and the pathogenesis of"consumptive disease"of TCM,and conducts evidence-based evaluation of the existing TCM in-tervention programs,so as to provide a new theoretical basis and treatment strategy for the clinical prevention and treatment of CRF.
