Legionella pneumophila pneumonia in a highly sensitized kidney transplant recipient: a case report
10.3760/cma.j.cn421203-20241111-00225
- VernacularTitle:高致敏肾移植受者嗜肺军团菌肺炎1例
- Author:
Shuliang YUAN
1
;
Guangyuan ZHAO
1
;
Huibo SHI
1
;
Dawei WANG
1
;
Hui GUO
1
;
Bin LIU
1
Author Information
1. 华中科技大学同济医学院附属同济医院器官移植研究所 器官移植教育部重点实验室 国家卫生健康委员会器官移植重点实验室 中国医学科学院器官移植重点实验室，武汉 430030
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Legionella;
Pneumonia;
Rejection
- From:
Chinese Journal of Organ Transplantation
2025;46(11):789-792
- CountryChina
- Language:Chinese
-
Abstract:
To summarize the diagnosis and management of a highly sensitized renal transplant recipient who developed Legionella pneumophila infection during the perioperative period. A 48-year-old male recipient presented early after transplantation with both acute allograft rejection and pulmonary infection. The acute rejection episode was successfully reversed with appropriate treatment, whereas the pulmonary infection continued to progress. Initial microbiological tests were negative, and empirical antimicrobial therapy was ineffective. Legionella pneumophila was subsequently detected by metagenomic next-generation sequencing of bronchoalveolar lavage fluid obtained via bronchoscopy. Following combined therapy with moxifloxacin and tigecycline, along with withdrawal of immunosuppressive agents, the pulmonary lesions completely resolved.
