Study on the Chemical Components of Lignans from the Root Bark of Schisandra Sphenanthera
10.14148/j.issn.1672-0482.2025.0813
- VernacularTitle:长胜七中木脂素类化学成分研究
- Author:
Yuxuan WANG
1
;
Yuanyuan LIU
1
;
Yuying ZHANG
1
;
Shiqi HUANG
1
;
Yuze LI
1
;
Chong DENG
1
;
Xiaomei SONG
1
;
Wei WANG
1
;
Dongdong ZHANG
1
Author Information
1. 陕西中医药大学药学院,陕西省太白七药研究与应用重点研究室,陕西 咸阳 712046
- Publication Type:Journal Article
- Keywords:
root bark of Schisandra sphenanthera;
Schisandra sphenanthera;
chemical components;
lignans;
cytotoxity
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2025;41(6):813-821
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study the chemical constituents in the root bark of Schisandra sphenanthera and their cytotoxic activ-ities.METHODS The compounds were isolated and purified by silica,Sephadex LH-20 and semi preparative-HPLC and the chem-ical structures were identified by 1 H-NMR,13 C-NMR and MS data analysis.The cytotoxic activities of the compounds were deter-mined by MTT method.RESULTS Twenty lignans were isolated and deduced as:Matairesinol(1),2-Hydroxy-2-(3′,4′-di-hydroxyphenyl)methyl-3-(3″,4″-dimethoxyphenyl)methyl-gamma-butyrolactone(2),(+)-Nortrachelogenin(3),2-Hydroxy-2-(4′-O-β-D-glucopyranosyl-3′-hydroxyphenyl)methyl-3-(3″,4″-dimethoxyphenyl)methyl-γ-butyrolactone(4),Nortracheloside(5),Burselignan(6),(+)-Cycloolivil(7),5-Methoxy-(+)-isolariciresinol(8),(-)-Isolariciresinol 3α-O-β-D-glucopyranoside(9),(+)-9-O-β-D-Glucopyranosyl lyoniresinol(10),(-)-Secoisolariciresinol(11),Licarin A(12),Cedrusin(13),Mataires-inol 4′-O-β-D-glucopyranoside(14),Pregomisin(15),Meso-dihydroguaiaretic acid(16),7S,8R-Erythro-4,9,9′-trihydroxy-3,3′-dimethoxy-8-O-4′-neolignan-7-O-β-D-glucopyranoside(17),Gomisin M2(18),Gomisin M3(19),Pinoresinol(20).Com-pounds 1-3,12,15,16,18 and 19 showed cytotoxic activity against A549,HCT116 and SW620 cell lines with IC50 values ranging from 1.4 to 22.9 μmol·L-1.CONCLUSION Compounds 1-4,6-12,14,17-19 are isolated from the plant for the first time,com-pounds 1-3,12,15,16,18 and 19 exhibit cytotoxic activities.
