Research progress on cAMP signaling pathway in the pathogenesis and intervention strategies of depression
10.3969/j.issn.1005-4847.2025.02.012
- VernacularTitle:cAMP信号通路在抑郁症发病机制及干预策略中的研究进展
- Author:
Jingxia LIU
1
;
Xinwang CHEN
;
Yajing GUO
;
Yongshu DONG
;
Yuchen GUO
Author Information
1. 河南中医药大学,郑州 450046
- Publication Type:Journal Article
- Keywords:
depression;
cAMP pathway;
PKA;
CREB;
BDNF;
signaling pathway
- From:
Acta Laboratorium Animalis Scientia Sinica
2025;33(2):267-274
- CountryChina
- Language:Chinese
-
Abstract:
Depression is a common mental illness that has a negative impact on patient quality of life,as well as representing a serious economic burden to society.The strategy of interfering with depression based on signaling pathways has recently attracted widespread attention.The cAMP pathway is an important cellular signaling pathway that plays a key role in the pathogenesis of and interventions for depression.In this review,we addresses recent studies on cAMP pathway-based interventions in depression,to provide a theoretical basis for regulating the cAMP pathway and its cascade mechanism in depression.
