Influence of oxycodone-acetaminophen combined with local radiotherapy on serum cytokines in elderly pa-tients with malignant tumor bone metastasis complicated with cancer pain
10.3969/j.issn.1006-5725.2025.11.016
- VernacularTitle:氨酚羟考酮联合局部放疗对老年恶性肿瘤骨转移癌痛患者血清细胞因子的影响
- Author:
Minghong SHI
1
;
Zhanwei LIU
;
Yang ZHU
;
Lili XIA
;
Gang CHENG
;
Youguo LU
Author Information
1. 淮南新华医疗集团新华医院 放疗科(安徽淮南 232000)
- Publication Type:Journal Article
- Keywords:
malignant tumor;
bone metastasis;
cancer pain;
elderly;
oxycodone-acetaminophen;
radiotherapy;
prostaglandinE2;
interleukin-6
- From:
The Journal of Practical Medicine
2025;41(11):1718-1723
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of combination of oxycodone-acetaminophen and local radiotherapy on serum cytokines in elderly patients with malignant tumor bone metastasis and cancer pain.Methods Eighty elderly patients with malignant tumor bone metastasis and cancer pain admitted to Huainan Xinhua Medical Group Xinhua Hospital from January 2020 to April 2024 were divided into control group(40 cases)and observa-tion group(40 cases)according to the order of admission.The control group received codeine combined with local radiotherapy,whereas the observation group was treated with oxycodone-acetaminophen combined with local radio-therapy.Pain relief(assessed using visual analogue scale(VAS)),daily fulminant pain occurrence frequency and occurrence of adverse reactions during treatment as well as serum cytokines[substance P(SP),prostaglandinE2(PGE2),interleukin-6(IL-6)],sleep quality(assessed using Pittsburgh sleep quality index(PSQI))and quality of life[assessed using functional assessment of cancer therapy-general(FACT-G)]before and after treatment were compared between the two groups..Results The pain relief effect in the observation group was better(P<0.05),and the daily occurrence frequency of fulminant pain was less than that in the control group(P<0.05).After treat-ment,serum levels of SP,PGE2 and IL-6 in the observation group were lower compared to those in the control group(P<0.05).The total incidence rate of bone-related events during treatment was not significantly different between the two groups(P>0.05),and the total incidence rate of adverse reactions was lower in the observation group compared to those in the control group(P<0.05).The PSQI score in the observation group after treatment was lower(P<0.05)while the scores of physiology and emotion of FACT-G were higher compared to those in the control group(P<0.05).Conclusion Oxycodone-acetaminophen combined with local radiotherapy can down-regulate the levels of serum SP,PGE2 and IL-6,relieve the pain,and improve the sleep quality and quality of life in elderly patients with malignant tumor bone metastasis complicated with cancer pain.
