Clinical pathological diagnosis of drug-induced liver injury after liver transplantation
10.3760/cma.j.cn421203-20241125-00232
- VernacularTitle:肝移植后药物性肝损伤的临床病理诊断
- Author:
Guangde ZHOU
1
Author Information
1. 首都医科大学附属北京佑安医院病理科，北京 100039
- Publication Type:Journal Article
- Keywords:
Liver Transplantation;
Drug induced liver injury;
Pathology
- From:
Chinese Journal of Organ Transplantation
2025;46(9):630-634
- CountryChina
- Language:Chinese
-
Abstract:
Drug-induced liver injury (DILI) is one of the major complications following liver transplantation and can lead to impaired graft function, and in some cases, graft failure. A wide range of drugs are implicated in DILI post-liver transplantation, including immunosuppressants, antiviral agents, antibiotics, and, more recently, immune checkpoint inhibitors. The histopathological manifestations of DILI in this context are complex and diverse, encompassing hepatocellular steatosis, necrosis, cholestasis, cholangitis, vascular lesions, and fibrosis. However, these features lack specificity, making the pathological diagnosis of post-transplant DILI challenging. This review focuses on the pathological aspects of diagnosing and differentiating DILI after liver transplantation, as well as recent advances in this field, combined with clinical considerations. The aim is to provide insights that may contribute to improving graft survival and prolonging the life expectancy of liver transplant recipients.
