The relationship between the time within the blood glucose target range and obstructive sleep apnea hypopnea syndrome in type 2 diabetes mellitus patients
10.3969/j.issn.1006-6187.2025.03.007
- VernacularTitle:2型糖尿病患者血糖目标范围内时间与阻塞性睡眠呼吸暂停低通气综合征相关性的研究
- Author:
Rong ZHANG
1
;
Suwan ZHANG
1
;
Wu DAI
1
Author Information
1. 230011 合肥市第二人民医院内分泌科
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type2;
Blood glucose fluctuation;
Obstructive sleep apnea hypopnea syndrome;
Time in range
- From:
Chinese Journal of Diabetes
2025;33(3):194-199
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between time within target range of blood glucose(TIR)and obstructive sleep apnea hypopnea syndrome(OSAHS)in type 2 diabetes mellitus(T2DM)patients.Methods 435 T2DM patients hospitalized in the Department of Endocrinology,Second People's Hospital of Hefei from January 2019 to September 2023 were selected.According to the sleep apnea hypopnea index(AHI)and the lowest blood oxygen saturation(LSaO2),they were divided into 270 simple T2DM patients(T2DM),100 diabetes patients with mild OSAHS(MOS)and 65 diabetes patients with moderate to severe OSAHS(SOS).The transient glucose monitoring system was used to complete dynamic glucose monitoring and calculate TIR.According to the 25th,50th and 75th percentile values of TIR,the study subjects were divided into four groups:Q1 group(TIR<51%),Q2 group(TIR 51%～65%),Q3 group(TIR 65%～78%)and Q4 group(TIR>78%).Results Compared with T2DM group,the TIR levels of patients in MOS and SOS groups decreased(P<0.05).Spearman correlation analysis showed a negative correlation between TIR and AHI(P<0.05),and a positive correlation with LSaO2(P<0.05).Compared with Q1 group,Q4 group had shorter duration of DM,lower levels of HbA1c,UACR and AHI,lower incidence of coronary heart disease and stroke(P<0.05),but higher levels of eGFR and LSaO2(P<0.05).Logistic regression showed that male,BMI,DBP,TC,UACR and HOMA-IR were the influencing factors for OSAHS.TIR levels were the influencing factors for OSAHS(OR 0.960,95%CI 0.937～0.982,P=0.004)and moderate and Severe OSAHS(OR 0.922,95%CI 0.879～0.974,P=0.002).Compared with Q4 group,the Q1 group had the highest risk of OSAHS(OR 3.745,95%CI 1.128～12.046,P=0.034).Conclusions In type 2 diabetes mellitus patients,men,BMI,DBP,TC,UACR,HOMA-IR are related to the occurrence of OSAHS,OSAHS is significantly related to the decline of TIR level.
