Influencing factors of glycemic fluctuation in type 2 diabetes mellitus patients with real-time dynamic glucose monitoring
10.3969/j.issn.1006-6187.2025.03.006
- VernacularTitle:实时动态血糖监测的2型糖尿病患者血糖波动的影响因素研究
- Author:
Ying SHEN
1
;
Chaoyang XU
1
;
Bei SHEN
1
;
Bei ZHOU
1
;
Yue LI
1
;
Ting PAN
1
;
Jun CHEN
1
;
Jun XIA
1
Author Information
1. 215228 苏州,南京医科大学附属江苏盛泽医院内分泌科
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Real-time dynamic blood glucose monitoring;
Blood glucose coefficient of variation;
Fasting C-peptide;
Serum uric acid
- From:
Chinese Journal of Diabetes
2025;33(3):189-193
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the factors affecting the coefficient of variation(CV)of glucose in type 2 diabetes mellitus(T2DM)patients based on real-time dynamic glucose monitoring system.Methods A total of 354 patients with T2DM hospitalized in the Department of Endocrinology of Jiangsu Shengze Hospital were enrolled in this study from March 2023 to March 2024 and divided into two groups:the glycemic variability(GV,CV>36%)group(n=118)and the glucose stable(GS,CV≤36%)group(n=236).The clinical data of the two groups were compared,and the influencing factors for CV>36%were analyzed.Results The DM duration and HbA1c were higher(P<0.05),while BMI,visceral fat area,subcutaneous fat area(SFA),FC-P,serum uric acid(SUA),and TG were lower in the GV group than in the GS group(P<0.05).Spearman correlation analysis showed that CV was positively correlated with diabetes duration and HbA1c(P<0.05),and negatively correlated with FC-P,SFA and SUA(P<0.05).Logistic regression analysis showed that DM duration,HbA1c,SFA,FC-P and SUA were the influencing factors for GV.Scatter plot analysis showed that there was a linear trend between CV level and log HbA1c and log SFA in T2DM patients.CV level increased with the increase of log HbA1c,and decreased with the increase of log SFA.ROC curve analysis showed that the area under the curve(AUC)of FC-P was 0.703(95%CI:0.640～0.765,P<0.001)for predicting GV in T2DM patients,and the cut-off value was 1.095 ng/ml.The AUC of SUA was 0.622(95%CI:0.555～0.688,P<0.001)for predicting GV,and the cut-off value was 280.5 μmol/L.Conclusions The DM duration,HbA1c,SFA,FC-P and SUA are important factors for GV,and FC-P and SUA have predictive value for GV.
