Research advances of gonadal function changes in kidney transplantation recipients
10.3760/cma.j.cn421203-20240422-00094
- VernacularTitle:肾移植受者性腺功能变化的研究进展
- Author:
Yizhong TU
1
;
Shuangjin YU
1
;
Jiang QIU
1
Author Information
1. 中山大学附属第一医院器官移植中心，广州 510080
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Hypogonadism;
Sex hormone;
Hypothalamic-pituitary-gonadal axis
- From:
Chinese Journal of Organ Transplantation
2025;46(2):166-170
- CountryChina
- Language:Chinese
-
Abstract:
Dysfunction of the hypothalamic-pituitary-gonadal axis (HPGA) is a key contributor to hypogonadism and sexual dysfunction in patients with end-stage renal disease (ESRD). Kidney transplantation is the preferred treatment for ESRD and has demonstrated beneficial effects in improving gonadal dysfunction and abnormal sex hormone levels in transplant recipients. However, inappropriate use of immunosuppressants may have adverse effects on gonadal function. For female kidney transplant recipients planning pregnancy, careful adjustment of immunosuppressive regimens-balancing risks and benefits-is essential. In male kidney transplant recipients, phosphodiesterase-5 inhibitors, intracavernosal alprostadil injections, and penile prosthesis implantation have been shown to be relatively safe options for managing erectile dysfunction. Despite these advancements, research on the treatment of hypogonadism in kidney transplant recipients remains limited, underscoring the urgent need for further studies to explore more effective therapeutic approaches. This review aims to provide an in-depth analysis of research progress on gonadal function changes in kidney transplant recipients, offering valuable insights for clinicians to optimize patient management.
