Advances in the induction of immune tolerance in allogeneic organ transplantation
10.3760/cma.j.cn421203-20240115-00010
- VernacularTitle:同种异体器官移植中免疫耐受诱导的研究进展
- Author:
Zhiqing XIANG
1
;
Sen ZENG
;
Leiyan WEI
;
Yizhou ZOU
Author Information
1. 长沙市望城区人民医院检验科，长沙 410203
- Publication Type:Journal Article
- Keywords:
Organ transplantation;
Allogeneic transplantation;
Transplantation rejection;
Immune tolerance
- From:
Chinese Journal of Organ Transplantation
2025;46(1):74-83
- CountryChina
- Language:Chinese
-
Abstract:
Organ transplantation is the preferred treatment for end-stage organ failure, However, the allogenic origin of donor tissues frequently provokes rejection by the recipient's immune system. Inducing a state of immune hyporesponsiveness specific to the transplanted cells and organs, referred to as near-immunotolerance, is the ideal approach to managing transplant rejection. Currently, various strategies have been explored to achieve immune hyporesponsiveness, including cell-based immune induction, chimerism induction, co-stimulatory pathway blockade, apoptosis induction, targeted clearance of memory T cells, and the use of exosomes or nanoparticles for drug delivery to induce tolerance. This review highlights the importance of achieving immune tolerance in clinical medicine to ensure the survival of both allografts and recipients. It provides an overview of the current status and advancements in tolerance-inducing strategies in allogeneic transplantation. Additionally, the review critically examines the limitations of these approaches and discusses future directions for research in this field.
