Hantavirus-induced central nervous system infectious after kidney transplantation: a case report
10.3760/cma.j.cn421203-20230719-00029
- VernacularTitle:肾移植术后汉坦病毒引起的中枢神经系统感染并发症1例
- Author:
Xingsong QIN
1
;
Lu LIU
1
;
He ZHAO
1
;
Wei QIN
1
;
Hongyu WANG
1
Author Information
1. 河南中医药大学第五临床医学院(郑州人民医院)器官移植中心，郑州 450531
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Hantavirus;
Central nervous system infection;
Complication
- From:
Chinese Journal of Organ Transplantation
2025;46(6):466-468
- CountryChina
- Language:Chinese
-
Abstract:
Hantavirus infection primarily causes hemorrhagic fever with renal syndrome (HFRS), leading to renal failure and systemic hemorrhage, while central nervous system (CNS) involvement is rare. In this case, a kidney transplant recipient was admitted due to memory loss and cognitive impairment without obvious precipitating factors. Metagenomic next-generation sequencing (mNGS) identified Hantavirus as the causative agent of CNS infection and its related complications. The patient achieved favorable outcomes through a combination of treatments, including ribavirin-based antiviral therapy, adjustment of immunosuppressive drug dosages, and immunomodulatory therapy with intravenous immunoglobulin (IVIG).
