Diagnosis of An Abbreviated Breast MRI Protocol Based on First Post-Contrast Subtracted for Breast Cancer
10.3969/j.issn.1005-5185.2025.05.014
- VernacularTitle:基于首次增强后减影图像的乳腺MRI简化方案对乳腺癌的诊断价值
- Author:
Xu HE
1
;
Tingting HUANG
;
Jiacheng ZHANG
;
Dingsheng HAN
;
Fukun SHI
;
Qian XU
;
Yanru ZHOU
;
Lan ZHANG
Author Information
1. 河南中医药大学,河南 郑州 450046;河南中医药大学第一附属医院MRI科,河南中医药大学中医药信息智能分析与利用郑州市重点实验室,河南 郑州 450000
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Magnetic resonance imaging;
Abbreviated protocol;
Diagnosis;
First post-contrast subtracted imaging;
Female
- From:
Chinese Journal of Medical Imaging
2025;33(5):531-536
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To evaluate the diagnostic value of an abbreviated protocol MRI(AP-MRI)based on first post-contrast subtracted(FAST)images for breast cancer detection.Materials and Methods This study included imaging data from 160 female patients with solid breast lesions who underwent breast MRI in the First Affiliated Hospital of Henan University of Chinese Medicine from April 2021 to January 2024.Two AP-MRI protocols were extracted from the full diagnostic protocol(FDP),including:dynamic contrast-enhanced MRI(DCE-MRI)A protocol:FAST and maximum-intensity projection(MIP)images,and DCE-MRI B protocol:FAST+MIP+diffusion-weighted imaging(DWI).Lesions categorized as breast imaging reporting and data system(BI-RADS)1-3 were classified as negative,and those categorized as BI-RADS 4-5 were classified as positive.Pathological findings served as the diagnostic gold standard.Two radiologists independently evaluated the lesions as negative/positive and compared with the gold standard.The sensitivity,specificity and accuracy of the three protocols were compared.Receiver operating characteristic curves were generated for each protocol,and the area under the curve(AUC)was compared.Results The accuracy of the three protocols showed statistically significant differences(Cochran's Qreader1=6.000,P=0.050;Cochran's Qreader2=10.909,P=0.012).The accuracy of the DCE-MRI A protocol was significantly lower than that of the FDP protocol(Z=2.449,Preader1=0.043;Z=2.858,Preader2=0.013).There were no statistically significant differences in sensitivity(Cochran's Qreader1=3.000,P=0.223;Cochran's Qreader2=2.667,P=0.264)or specificity(Cochran's Qreader1=3.000,P=0.223;Cochran's Qreader2=2.800,P=0.247)between the two AP-MRI protocols and the FDP protocol.There were no statistically significant differences in AUC between the DCE-MRI B protocol and the FDP protocol(Z=1.390-1.719,all P>0.05),while the AUC of the DCE-MRI A protocol had lower AUCs than the FDP protocol(Z=1.980,2.441;both P<0.05).Conclusion The AP-MRI protocol combining FAST,MIP and DWI shows diagnostic accuracy comparable to that of the FDP and greatly saves time and cost,suggesting its potential as an alternative imaging strategy for women with dense breasts and as a new diagnostic approach for high-risk populations.
