Diagnosis of Low-Iodine Contrast CT Pulmonary Angiography Combined with Iodine Maps in Acute Pulmonary Embolism
10.3969/j.issn.1005-5185.2025.05.013
- VernacularTitle:低碘对比剂下CT肺动脉造影联合碘图诊断急性肺栓塞的应用价值
- Author:
Xiaotong LIU
1
;
Chunyan TIAN
;
Jing WANG
;
Xiaomao XU
;
Tao GU
Author Information
1. 北京医院放射科,国家老年医学中心,中国医学科学院老年医学研究院,北京 100730;北京协和医学院,中国医学科学院,北京 100730
- Publication Type:Journal Article
- Keywords:
Acute pulmonary embolism;
Computed tomography pulmonary angiography;
Subtraction computed tomography;
Single photon emission computed tomography computed tomography;
Low-dose iodine contrast agent;
Diagnosis
- From:
Chinese Journal of Medical Imaging
2025;33(5):525-530
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To evaluate the diagnostic accuracy of low-iodine contrast subtraction CT pulmonary angiography(CTPA)combined with iodine maps for acute pulmonary embolism(APE),with a focus on detecting subsegmental emboli.Materials and Methods A retrospective analysis included 48 patients with suspected APE who underwent both pulmonary ventilation/perfusion SPECT/CT and low-iodine subtraction CTPA within one week in Beijing Hospital from September 1,2021 to September 1,2024.Using SPECT/CT as the reference standard,the diagnostic performance of subtraction CTPA with iodine maps was assessed.A retrospective review was performed to identify potential causes of false-positive and false-negative results.Results Subtraction CTPA with iodine maps demonstrated high diagnostic accuracy at the segmental and subsegmental pulmonary artery levels,with a sensitivity of 0.917 and specificity of 0.991.At the segmental level,the detection rate was 100%,while at the subsegmental level,it was 66.7%.The method showed consistently high diagnostic performance(83.3%-100%)across different clinical risk stratifications of APE.Retrospective review identified explicable causes for 85.7%(6/7)of false-positive and 33.3%(2/6)of false-negative cases.Conclusion Low-iodine subtraction CTPA combined with iodine maps exhibits robust diagnostic efficacy for APE.Accurate recognition of characteristic perfusion defects on iodine maps may further enhance diagnostic precision.
