Acute graft-versus-host disease after simultaneous pancreas and kidney transplantation: one case report
10.3760/cma.j.cn421203-20230825-00060
- VernacularTitle:胰肾联合移植后急性移植物抗宿主病1例
- Author:
Lu HU
1
;
Jianming ZHENG
;
Yeqi NIAN
;
Zhen WANG
;
Hui WANG
;
Gang FENG
;
Jie ZHAO
;
Wenli SONG
Author Information
1. 天津医科大学一中心临床学院，天津 300041
- Publication Type:Journal Article
- Keywords:
Simultaneous pancreas-kidney transplantation;
Acute graft versus host disease;
Complication
- From:
Chinese Journal of Organ Transplantation
2024;45(12):907-910
- CountryChina
- Language:Chinese
-
Abstract:
One case of acute graft-versus-host disease (aGVHD) after simultaneous pancreas and kidney (SPK) transplantation was described. The recipient exhibited typical clinical manifestations, including fever, abnormal liver function tests, intestinal obstruction, rash and myelosuppression since Day 17 post-SPK. The proportion of donor-derived cell-free DNA (dd-cfDNA) in blood was 8.66%, confirming a diagnosis of aGVHD. Despite high-dose glucocorticoid pulse therapy, patient status rapidly deteriorated and death due to multi-organ failure occurred at Day 24 post-SPK.
