Gray Matter Volume Changes in Migraine Patients Using 7T Magnetic Resonance Imaging and Voxel-Based Morphometry
10.3969/j.issn.1005-5185.2025.05.003
- VernacularTitle:基于7T磁共振成像及体素形态学测量研究偏头痛患者脑灰质体积的变化
- Author:
Xun PEI
1
;
Yanliang MEI
;
Xue ZHANG
;
Yu'an LI
;
Tong CHEN
;
Yuanbin ZHAO
;
Yonggang WANG
;
Binbin SUI
Author Information
1. 首都医科大学附属北京天坛医院 国家神经系统临床疾病研究中心 天坛神经影像研究中心,北京 100071;首都医科大学附属北京天坛医院放射科,北京 100071
- Publication Type:Journal Article
- Keywords:
Migraine;
Magnetic resonance imaging;
Ultra-high field;
Voxel-based morphometry;
Gray matter
- From:
Chinese Journal of Medical Imaging
2025;33(5):461-466
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the characteristics of gray matter(GM)volume changes in migraine patients using 7T MRI and voxel-based morphometry(VBM).Materials and Methods This prospective study enrolled 30 migraine patients and 41 age-and gender-matched healthy controls from Beijing Tiantan Hospital,Capital Medical University between November 2023 and November 2024.All participants underwent 7T MRI with 3D T1-weighted magnetization-prepared two rapid gradient-echo(MP2RAGE)sequences for structural brain imaging.VBM analysis was performed to quantify GM,white matter,cerebrospinal fluid and total brain volumes,followed by calculations of their relative percentages.The difference in GM volume between the two groups was compared to identify brain regions with characteristic GM volume changes in migraine patients.And the correlation between these characteristic GM volume alterations and clinical scales was analyzed.Results Migraine patients exhibited significantly lower total GM volume compared to healthy controls(t=2.096,P=0.040),while no group differences were observed in white matter or cerebrospinal fluid volumes(t=0.980,0.151;P=0.330,0.880).VBM analysis revealed reduced GM volume in the left orbitofrontal cortex(t=4.301,P=0.022),left hippocampus(t=5.226,P=0.006)and left parahippocampal gyrus(t=3.960,P=0.040)in the migraine group.Negative correlations were identified between:left orbitofrontal cortex GM volume and headache duration(r=-0.506,P=0.008),left hippocampal GM volume and patient health questionnaire-9 scores(r=-0.620,P=0.003),and left parahippocampal GM volume and visual analogue scale scores(r=-0.449,P=0.019).Conclusion VBM analysis based on 7T MP2RAGE data demonstrates characteristic GM volume reductions in the left orbitofrontal cortex,left hippocampus and left parahippocampal gyrus in migraine patients,with these structural alterations significantly correlate with depressive symptoms and headache burden.The observed microstructural abnormalities may reflect underlying pathophysiological mechanisms related to pain processing,emotional regulation and long-term disease burden in migraine.
