Role of exosomes derived from mesenchymal stem cells in treatment of colorectal cancer
- VernacularTitle:间充质干细胞衍生外泌体在结直肠癌治疗中的作用
- Author:
Zhao GUO
1
;
Haoyan ZHUANG
;
Xuewen SHI
Author Information
- Publication Type:Journal Article
- Keywords: mesenchymal stem cell; exosome; colorectal cancer; chemotherapy; mechanism; potential target; carrier; engineered stem cell; review
- From: Chinese Journal of Tissue Engineering Research 2025;29(36):7872-7879
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:Currently,the treatment methods for colorectal cancer include surgical resection and chemotherapy.However,the subsequent quality of life of patients cannot be improved due to the multiple surgical complications and drug resistance in the later stage of chemotherapy.OBJECTIVE:To review the mechanism of action,latest progress and existing problems of exosomes derived from mesenchymal stem cells in the treatment of colorectal cancer.METHODS:PubMed,CNKI and WanFang databases were searched for relevant literature using the search terms of"mesenchymal stem cells exosomes,colorectal cancer,chemotherapy,treatment"in Chinese and English,respectively.Finally,96 articles were included for analysis.RESULTS AND CONCLUSION:(1)Mesenchymal stem cell-derived exosomes play different roles in the treatment of colorectal cancer mainly through the microRNAs and long-chain non-coding RNAs carried by themselves to mediate different signaling pathways.(2)Mesenchymal stem cell-derived exosomes are highly stable and biocompatible,which makes them excellent carriers of therapeutic drugs.(3)Mesenchymal stem cell-derived exosomes have different effects on resistance to different types of chemotherapeutic agents.
