Association between different types of tea intake and risk of COVID-19 infection:a two-sample Mendelian randomization study
10.16753/j.cnki.1008-2344.2025.02.009
- VernacularTitle:不同类型茶摄入与COVID-19感染风险之间的关系:一项基于双样本孟德尔随机化研究
- Author:
Congzhi WANG
1
;
Binghong BAO
;
Ziyue ZHANG
;
Kang ZHAO
;
Yulu ZHANG
;
Liu YANG
;
Lin ZHANG
;
Dongmei ZHANG
;
Xiaoping LI
;
Min WANG
Author Information
1. 皖南医学院护理学院,安徽 芜湖 241001;山东大学护理与康复学院
- Publication Type:Journal Article
- Keywords:
tea intake;
covid-19;
infection;
two sample;
mendelian randomization study
- From:
Journal of Shenyang Medical College
2025;27(2):160-167
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between different types of tea intake and COVID-19 infection.Methods:Data were retrieved from a genome-wide association study(GWAS),involving 447 485,and 64 949 people for single nucleotide polymorphisms(SNPs).Two-sample Mendelian randomization(MR)analysis was used to investigate the relationship of different types of tea intake with four subgroups of COVID-19 infected population,including COVID-19 infected population versus general population,COVID-19 hospitalized population versus general population,COVID-19 hospitalized population versus non-hospitalized population,and very severe respiratory confirmed population versus general population.Inverse-variance weighted(IVW)method was used as the main method of causal analysis.MR Egger intercept was used for pleiotropy test,and Cochran's Q-statistic was used for heterogeneity test.Results:Compared to the general population,tea intake decreased the incidence of COVID-19 in the infection population(IVW method,OR=0.806,95%CI:0.651-0.999),and the hospitalized population(IVW method,OR=0.533,95%CI:0.369-0.770).Additionally,the underlying pleiotropy was not found following the MR-Egger regression intercept(MR intercept=-0.002,P=0.667),and the Cochran's Q-statistic showed no heterogeneity(Q-statistic=52.712,P=0.057).Compared to the general population,the underlying pleiotropy in the hospitalized patients was not found by MR-Egger regression intercept(MR intercept=-0.001,P=0.909),and the Cochran's Q-statistic showed no heterogeneity(Q-statistic=25.214,P=0.945).However,green tea and herbal tea had no effect on COVID-19 infection.Conclusions:Overall tea intake reduces the risk of COVID-19 infection in the general population compared to COVID-19 infected and hospitalized populations,while green tea and herbal tea have no protective effect against COVID-19 infection.
