Therapeutic effect of compound kushen injection combined with fentanyl transdermal patch in the treatment of carcinoma pain
- VernacularTitle:复方苦参注射液联合芬太尼透皮贴治疗癌性疼痛的疗效观察
- Author:
Jingjing ZHANG
1
;
Lili XIAO
1
;
Xinjie ZHANG
1
Author Information
- Publication Type:Journal Article
- Keywords: cancer pain; pain measurement; inflammation; comparative effectiveness research; compound kushen injection; fentanyl transdermal patch
- From: Tianjin Medical Journal 2025;53(3):317-320
- CountryChina
- Language:Chinese
- Abstract: Objective To observe the clinical efficacy of compound kushen injection combined with fentanyl transdermal patch for the treatment of final stage cancer pain.Methods A total of 100 patients with cancer pain were divided into 2 groups of 50 patients each according to the randomized numerical table method.The control group was treated with fentanyl transdermal patch only,and the observation group was treated with fentanyl transdermal patch combined with compound kushen injection.The KPS score,NRS score,pain relief rate after treatment,incidence of adverse reactions and effect on levels of inflammatory factors IL-6,IL-8 and CRP were compared between the two groups.Results The pain relief rate of the observation group was significantly better than that of the control group(P＜0.05).After treatment,the KPS score of the observation group was higher than that of the control group(P＜0.05),and the incidence of NRS score,IL-6,IL-8,CRP levels and gastrointestinal reactions were lower than those of the control group(P＜0.05).There were no significant differences in the incidence of hepatic and renal damage,dizziness and somnolence between the two groups(P＞0.05).Conclusion Compound kushen injection combined with fentanyl transdermal patch can effectively improve cancer pain,reduce the release of inflammatory factors,improve the patient quality of life,and the incidence of adverse reactions is low.
