Correlation analysis of HMGB1 and MCP-1 levels and prognosis of patients with sepsis combined with AKI
10.11958/20242035
- VernacularTitle:HMGB1、MCP-1水平与脓毒症合并AKI患者预后的相关性
- Author:
Man NI
1
;
Jun GE
1
;
Ziang KONG
1
Author Information
1. 佳木斯中心医院肾内科(邮编 154002)
- Publication Type:Journal Article
- Keywords:
sepsis;
acute kidney injury;
continuous renal replacement therapy;
prognosis;
HMGB1 protein;
MCP-1
- From:
Tianjin Medical Journal
2025;53(3):297-301
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between the levels of high mobility group protein B1(HMGB1),monocyte chemotactic protein-1(MCP-1)and the prognosis of patients with sepsis combined with acute kidney injury(AKI).Methods A total of 100 patients with sepsis combined with AKI treated with continuous renal replacement therapy(CRRT)were included in this study and clinical data before treatment were collected.The levels of HMGB1 and MCP-1 were detected by enzyme-linked immunosorbent assay before and after CRRT treatment.Follow-up began on the day after the end of CRRT treatment,and the end point of follow-up was death or survival within 30 days.Patients were divided into the death group(31 cases)and the survival group(69 cases)according to survival status.Cox regression was used to analyze the relationship between HMGB1 and MCP-1 and death within 30 days after CRRT in patients with septic AKI.Receiver operating characteristics(ROC)curve was used to analyze the prognostic value of HMGB1 and MCP-1 in patients with sepsis combined with AKI after CRRT.Resluts The sequential organ failure(SOFA)scores,acute physiology and chronic healthⅡ(APACHE Ⅱ)scores were lower in the survival group than those in the death group(P＜0.05).After CRRT treatment,HMGB1 and MCP-1 levels were lower in the survival group than those in the death group(P＜0.05).Cox regression analysis showed that SOFA score,APACHE Ⅱscore,HMGB1 and MCP-1 increase after treatment were risk factors for death in patients with sepsis complicated with AKI.ROC curve analysis showed that the AUC of SOFA score,APACHE Ⅱ score,combined diagnosis of HMGB1 and MCP-1 after treatment was 0.973,which was significantly higher than that of single detection(P＜0.05).Conclusion The increased levels of HMGB1 and MCP-1 in peripheral blood after treatment are independent risk factors for 30-day death in patients with sepsis complicated with AKI after CRRT treatment,and the combined prognostic value is high.
