HIC relationship of anterior-posterior and lateral-medial collisions based on the comprehensive evaluation of injury
10.3969/j.issn.1005-202X.2025.03.018
- VernacularTitle:基于综合损伤程度的大鼠颅脑前后向-侧向碰撞HIC关系
- Author:
Linna ZHU
1
;
Guoxiang WANG
1
;
Xun WANG
1
;
Qinghang LUO
1
;
Tao XIONG
1
;
Qiuju CHEN
1
;
Jingyu XU
1
;
Jia YU
1
;
Shengxiong LIU
1
Author Information
1. 重庆理工大学药学与生物工程学院生物医学工程系,重庆 400054
- Publication Type:Journal Article
- Keywords:
traumatic brain injury;
head injury criterion;
impact injury biomechanics;
animal experiment
- From:
Chinese Journal of Medical Physics
2025;42(3):406-414
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the head injury criterion(HIC)values in anterior-posterior(AP)collisions and lateral-medial(LM)collisions.Methods A total of 102 male SD rats were randomly divided into a control group of 0 m(6 rats),4 AP groups(12 rats/group)and 4 LM groups(12 rats/group).After adaptive training,the classical Marmarou model was used to execute the brain AP and LM collisions under a series of different height impacts,and the HIC values were calculated.The experimental group data of the walk-pole test and grip strength test were collected at 24 hours before and after injury,and the data of the proportion of hemorrhage in the corpus callosum and pyramidal tracts were collected at 24 hours after injury.Results As the collision heights increased in both AP and LM groups,there were positive correlations with changes in WP test time and peak GS,and corresponding increases in the proportion of hemorrhage in the cc and py.According to the mathematical relationships between the comprehensive injury degrees and HIC values,it was found that at the same injury degree,LM-HIC value was less than AP-HIC value.A mathematical relationship between AP-HIC and LM-HIC was fitted based on the comprehensive injury degrees.At the same HIC,LM group experienced more severe injuries,and AP group was more tolerant to head collision.Conclusion The injury severity in LM group is greater than that of AP group at the same HIC.Preliminary results show there is a linear mathematical relationship between AP-HIC and LM-HIC.These results can be expected to expand the application scope of HIC and achieve an accurate assessment of the LM collision severity.
