Research progress on mitochondrial homeostasis in vascular cognitive impairment
10.3969/j.issn.1006-5725.2025.12.024
- VernacularTitle:线粒体稳态在血管性认知障碍中的研究进展
- Author:
Linghui DAI
1
;
Weifeng LI
1
Author Information
1. 河南中医药大学康复医学院(河南 郑州 450046)
- Publication Type:Journal Article
- Keywords:
vascular cognitive impairment;
mitochondrial homeostasis;
mitochondrial biology;
neu-roprotection
- From:
The Journal of Practical Medicine
2025;41(12):1936-1944
- CountryChina
- Language:Chinese
-
Abstract:
Vascular cognitive impairment(VCI)is a type of cognitive dysfunction caused by cerebrovascular lesions,and its pathological mechanism includes mitochondrial damage.Therefore,maintaining mitochondrial homeostasis is crucial in the occurrence and progression of VCI.Mitochondrial homeostasis involves multiple levels,including biogenesis,autophagy,ion balance,protein quality control,membrane dynamics,and interactions with other organelles.This study outlines the regulatory mechanisms of mitochondrial homeostasis dysregulation at both the micro and macro levels,delves into the key role of mitochondrial homeostasis in VCI,analyzes potential therapeutic directions,and provides new scientific evidence and perspectives for the early diagnosis and treatment of VCI.
