The correlation between serum P-Tau181,GGT,SIRT1 and sleep disorders in patients with cerebral small vessel disease
10.3969/j.issn.1006-5725.2025.12.014
- VernacularTitle:脑小血管病患者血清磷酸化Tau蛋白-181、γ-谷氨酰转肽酶、沉默信息调节因子1与睡眠障碍的相关性
- Author:
Li ZHANG
1
;
Yunting FU
Author Information
1. 南京医科大学第三附属医院(常州市第二人民医院)神经内科(江苏 常州 213000)
- Publication Type:Journal Article
- Keywords:
cerebral small vessel disease;
sleep disorders;
P-Tau181;
GGT;
SIRT1
- From:
The Journal of Practical Medicine
2025;41(12):1867-1872
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between serum phosphorylated Tau protein-181(P-Tau181),gamma glutamyl transpeptidase(GGT),silent information regulator 1(SIRT1)and sleep disorders in patients with cerebral small vessel disease.Methods A total of 156 patients with cerebral small vessel disease(CSVD)were divided into a sleep disorder group(PSQI≥10)and a normal sleep group(PSQI<10)based on the Pittsburgh Sleep Quality Index(PSQI)scores.Serum levels of P-Tau181,GGT,and SIRT1 were compared between the two groups,and the predictive value of these biomarkers for the development of sleep disorders in CSVD patients was analyzed.Results Among 156 patients with cerebral small vessel disease(CSVD),52(33.33%)were diag-nosed with sleep disorders,and their Pittsburgh Sleep Quality Index(PSQI)scores were significantly higher than those of the normal sleep group(P<0.05).The serum levels of P-Tau181,GGT,and SIRT1 in the sleep disorder group were elevated compared to the normal sleep group(P<0.05).Positive correlations were observed between PSQI scores and P-Tau181,GGT,and SIRT1 levels(P<0.05).The areas under the curve(AUC)for predicting sleep disorders in CSVD patients using individual biomarkers(P-Tau181,GGT,SIRT1)and their combined prediction were 0.672,0.742,0.749,and 0.843,respectively.Conclusion The abnormal expression of P-Tau181,GGT,and SIRT1 is associated with sleep disorders in patients with cerebral small vessel disease.
